Conception and pregnancy
*RI : Reference Intakes
Food supplement
Vitamin B9, or folic acid, is part of the B-vitamin group, classified as "water-soluble" vitamins (soluble in water). It is not stored in the body, which is why it is crucial to ensure a regular intake through diet or supplementation.
Vitamin B9 is primarily found in leafy green vegetables, which is why it is called "folic," derived from the Latin word "folium" meaning "leaf." Lettuce and spinach are particularly exceptional sources of this vitamin. It is also found in significant amounts in cereals, certain cheeses, and animal livers such as lamb, veal, and poultry. Vitamin B9 plays a key role in the folate cycle, which is a crucial biological process for many body functions. The folate cycle is a process in which vitamin B9 is converted into various active forms that can be used by the body. As a water-soluble vitamin, it is quickly eliminated by the kidneys, posing a low risk of overdose. Therefore, it is particularly important during periods such as pregnancy. It contributes to the normal growth of maternal tissues from conception and throughout pregnancy, as well as the normal metabolism of homocysteine. It also plays a role in DNA synthesis, cell division, red blood cell formation, and the normal functioning of the nervous system.
A deficiency in vitamin B9 can have significant health consequences. In pregnant women, a deficiency increases the risk of neural tube defects in the fetus. However, modern diets, often depleted of essential nutrients, make it sometimes difficult to achieve sufficient intake.
PHYSIOMANCE® Vitamine B9 is a single-ingredient formula with a high concentration, providing 600 µg of vitamin B9 per capsule.
The choice of bioavailable ingredients ensures optimal absorption and enhanced effectiveness.
Thus, vitamin B9 has been selected in its coenzymated biologically active form: calcium L-methylfolate, directly assimilable by the body without prior enzymatic transformation, unlike folic acid. This innovative form is particularly recommended for overcoming a mutation (polymorphism) of the methylenetetrahydrofolate reductase (MTHFR) affecting up to 40% of the population. The enzyme's activity is impaired, reducing its ability to metabolize folic acid into active folate. Thanks to its high tolerance and excellent stability, PHYSIOMANCE® Vitamine B9 is suitable for all situations requiring a safe and effective folate intake, including preconception, pregnancy, breastfeeding, or chronic fatigue.
As part of a quality approach and commitment to naturalness, PHYSIOMANCE® Vitamine B9 is packaged in 100% plant-based capsules, making it suitable for vegetarian or vegan diets. This choice guarantees an approach perfectly aligned with your quality and efficacy requirements.
According to the health claims authorized by the EFSA (European Food Safety Authority), folates (vitamin B9):
Highly Concentrated Formula
During pregnancy and breastfeeding, the need for vitamin B9 increases significantly. Indeed, this vitamin plays a crucial role in the development of the fetal nervous system, especially during the early weeks of pregnancy. Sufficient intake of vitamin B9 helps reduce the risk of neural tube defects. That is why health authorities recommend a daily supplementation of 600 µg for pregnant women and 500 µg for breastfeeding women. An adequate supplementation, started at least one month before conception and continued up to 3 months after conception, is often recommended to ensure optimal intake.
Beyond the risk of embryonic malformation in women of childbearing age, a deficiency in vitamin B9 can manifest as severe fatigue, anemia, or more serious symptoms.
PHYSIOMANCE® Vitamine B9 provides 600 µg of calcium L-methylfolate per capsule, which is 300% of the reference intake for vitamin B9.
Optimal Bioavailability
THERASCIENCE Laboratory prioritizes active ingredients in their most bioavailable forms to ensure optimal absorption and assimilation in the body.
Bioavailability refers to the amount of a substance that reaches the bloodstream or the site of action in the body after being administered or consumed. The higher the bioavailability, the more efficiently the vitamin is absorbed. That is why we systematically choose coenzymated vitamins, minerals in the form of organic salts, and bioactive compounds directly assimilable by the cells.
The vitamin B9 used in PHYSIOMANCE® Vitamine B9 is in its coenzymated form: calcium L-methylfolate, also known as 5-MTHF (5-methyltetrahydrofolate). This form has better bioavailability than dietary folates and folic acid, ensuring immediate activation and requiring no further transformation once in the body. It can therefore be used immediately in metabolic reactions, leading to enhanced effectiveness.
For absorption by the body, dietary folates and synthetic folic acid must first be converted into simpler forms by an enzyme in the intestine. Once this step is completed, they are transported into the cells within the enterocytes, where they can be converted into 5-MTHF, the biologically active form of vitamin B9.
However, some individuals have a genetic variation that limits their ability to perform this conversion, reducing the effectiveness of traditional folic acid metabolism and making the assimilation of vitamin B9 less than optimal. In these cases, direct supplementation with 5-MTHF provides a more suitable solution to ensure efficient and usable intake by the body. The L-methylfolate form of calcium also helps quickly address deficiencies, offering a more effective approach to supply the body with essential elements for many metabolic reactions, while ensuring numerous significant benefits in terms of absorption, efficacy, and stability.
Single-Ingredient Supplement
Discover Therascience’s single-ingredient range, developed by our laboratory, experts in Physionutrition! To ensure effective supplementation tailored to each individual’s needs, the THERASCIENCE Laboratory offers a wide range of single-ingredient formulas, always guaranteeing product quality and the efficacy of its active ingredients.
Therascience’s single-ingredient supplements offer:
Enhanced naturalness
Safe use in case of intolerances
THERASCIENCE Laboratory adapts to all dietary habits: PHYSIOMANCE® Vitamin B9 is guaranteed gluten-free and lactose-free.
PHYSIOMANCE® Vitamin B9 is designed with a 100% plant-based capsule shell. HPMC (hydroxypropylmethylcellulose or hypromellose) is the main material used to form the shell of the plant-based capsules. HPMC is a derivative of cellulose, a natural substance found in plant cell walls. It is widely used in the formulation of dietary supplements due to its remarkable properties and safety for health, offering an effective alternative to traditional gelling agents of animal or synthetic origin. One of the main advantages of HPMC is its biodegradability, making it an environmentally friendly choice compared to other coating materials. By using HPMC as an excipient, the THERASCIENCE Laboratory can guarantee not only the safe and effective delivery of the product but also meet growing consumer concerns about quality, safety, and sustainability.
Did you know it ?
During foetal development, in the first few weeks of pregnancy, the neural tube is formed. This is an embryonic structure responsible for the normal development of the brain and spinal cord. A defect in the closure or development of the neural tube can cause physical and neurological problems in the unborn child. Research has shown the importance of vitamin B9 supplementation in ensuring the normal development of the neural tube, hence the importance of taking vitamin B9 supplements as soon as the pregnancy is planned and during the first few months of pregnancy.
1 capsule per day, for at least 3 months. To be renewed if necessary.
Directions for use :
Not recommended to children and teenagers.
Food supplements should be used as part of a healthy lifestyle and must not be used as a substitute for a varied and balanced diet. Do not exceed recommended daily dose. Keep this product out of the reach of young children. If using several dietary supplements, ask your healthcare professional for guidance.
Bulking agent: acacia gum, plant origin coating : hydroxypropyl methylcellulose, anti-caking agent: fatty acids, vitamin B9 (calcium-L-methylfolate).
| For 1 capsule | %RI* | |
| Vitamin B9 | 600,0 µg | 300 |
*RI : Reference Intake
Back to school: boost your immune defences and those of your loved ones!
Recommandé par mon médecin, je l'utilise régulièrement, avec de tvoir plus
Avis du 28/09/2024, suite à une expérience du 11/09/2024 par Silvia S