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Physiomance

GLP-1 Protect

Support for Anti-Diabetic Treatments with GLP-1 and GIP Analogues

Synergistic combination of 3 plants (Ginger, Griffonia, Saffron) and 1 mushroom (Hericium erinaceus);
Helps maintain digestive comfort, thanks to ginger extract ;
Ginfort^®: Patented ginger extract with the highest concentration of gingerols (26%), solvent-free, and clinically proven efficacy;
Safr’Inside^TM : Innovative patented process ensuring the quality and efficacy of saffron extracts;
Enhanced naturality : 100% plant-based capsules.

Ginfort^® is a registered trademark of Olene Life Sciences
Safr'Inside™ is a registered trademark of Activ'Inside

PHY533 - 60 capsules

1 Unit

Not available

£56.90

Pack of 3

Not available

£52.35 / unit

Pack of 6

Not available

£50.64 / unit

Description

Food supplement

GLP-1 and GIP receptor agonists are groundbreaking treatments originally developed for diabetes, now also employed in managing obesity. These molecules mimic the action of two natural hormones involved in metabolism and appetite regulation: GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide). Some formulations, like tirzepatide, combine these two mechanisms, while others, such as retatrutide, add an action on glucagon, making them triple agonists.
GLP-1, an incretin hormone produced in the gut, primarily stimulates insulin secretion based on blood glucose levels. It also reduces glucagon production, a hormone that promotes glucose release from the liver, and slows gastric emptying, contributing to a feeling of satiety. This action, further enhanced by its effects on the brain, leads to appetite suppression and reduced food intake.
GIP, on the other hand, also stimulates insulin release in the presence of glucose and plays a complementary role in energy metabolism regulation. Glucagon increases blood glucose levels, particularly during fasting, and facilitates the mobilization of energy reserves.
Synthetic agonists like semaglutide and tirzepatide are stable peptides that specifically activate the receptors of these hormones, amplifying their beneficial effects on glycemic control and weight management. While effective, these treatments require monitoring due to potential side effects, especially in non-diabetic patients. This therapeutic advancement represents a revolution in the management of metabolic diseases and obesity.
Despite their efficacy in managing obesity and metabolic disorders, GLP-1 and GIP receptor agonists can cause side effects, which are a common reason for therapy discontinuation. Gastrointestinal issues such as nausea, vomiting, diarrhea, and abdominal pain are among the most frequently reported side effects, especially at the start of treatment. Other adverse effects, including depression, sleep disturbances, and anxiety, have also been noted. While these side effects are usually transient, they can be bothersome enough to prompt some patients to discontinue treatment prematurely. Stopping the therapy often leads to rapid weight regain, undermining long-term benefits. Early and tailored management of these side effects is essential to help patients continue their treatment under optimal conditions and maximize its effectiveness. Personalized medical support can prevent or mitigate these symptoms, improving adherence and the overall success of the therapy.

Why choose PHYSIOMANCE^® GLP-1 Protect?

PHYSIOMANCE^® GLP-1 Protect is a unique combination of four bioactive ingredients delivered in the form of standardized extracts, each titrated for active molecules:

Ginfort^® patented ginger extract, titrated at 26% gingerols;
Griffonia extract, titrated at 26% 5-HTP (5-hydroxytryptophan);
Saf’Inside™ patented saffron extract, titrated at 2% safranal and 3% crocins;
Organic Hericium erinaceus mushroom extract, from organic farming, titrated at 30% polysaccharides

PHYSIOMANCE^®GLP-1 Protect is supported by validated clinical studies and represents a new approach to nutritional prevention.

It is important to note that PHYSIOMANCE^® GLP-1 Protect does not replace GLP-1 and GIP agonist treatments, nor does it act directly on these hormones. Instead, it has been specifically formulated to complement these treatments, which are often associated with numerous side effects.

What does the science say ?
The bioactive compounds in PHYSIOMANCE^® GLP-1 Protect have undergone thorough scientific evaluation by the European Food Safety Authority (EFSA).

Ginger helps maintain digestive comfort.
Griffonia stimulates brain activity and provides 5-HTP (a precursor of serotonin).
Saffron contributes to emotional balance. It helps promote relaxation and maintain a positive mood.

Hericium is the subject of numerous scientific studies, and its biological mechanism of action is well-documented in the literature. Multiple studies highlight its potential applications in prevention. However, to date, European legislation has not approved any health claims for Hericium. Although no specific benefits are officially recognized, this mushroom, widely used in mycotherapy, is gaining increasing interest and offers promising prospects that deserve further exploration

Key benefits of PHYSIOMANCE^® GLP-1 Protect ?

Synergistic association

PHYSIOMANCE^® GLP-1 Protect has been specifically designed to support individuals undergoing GLP-1 agonist treatments, often associated with numerous side effects. This innovative formula combines patented bioactive extracts of Ginfort^® ginger, Griffonia, Safr’Inside™ saffron, and Hericium erinaceus mushroom.

Ginger (Zingiber officinale), a root with numerous health benefits, has been used in traditional medicine for millennia. Its beneficial effects are attributed to its "gingeroids," a group of phenolic compounds that include gingerols and shogaols, responsible for ginger's pungent taste and therapeutic properties
Ginfort^® features the highest concentration of gingeroids on the market (26%), extracted solvent-free, with clinically proven efficacy in alleviating dyspepsia symptoms.
Digestive Support for GLP-1 Treatments: GLP-1 agonists frequently cause digestive side effects, with nausea occurring in 40% of cases, vomiting in 25%, and bowel disturbances in 23%, often leading to treatment discontinuation (Sun F et al., Diabetes Technology & Therapeutics, 2015). Ginfort^® provides a natural solution to mitigate these issues.

Safran Safr’Inside™ : Saffron, derived from the stigmas of the Crocus sativus flower, is a precious spice renowned for its unique properties. Used for millennia, it contains active compounds such as crocins and safranal, known for their beneficial effects on emotional balance, relaxation, and mood—key elements of well-being. The result of over 3,000 years of ancestral expertise, our saffron is meticulously harvested. Only the tips of the stigmas, particularly rich in active compounds, are carefully selected. To ensure impeccable quality, the extraction process is conducted in France using an exclusive patented method: Tech’Care™. This innovative technology preserves the integrity of saffron’s active molecules, preventing any alteration during the process. It maintains saffron’s native and complete composition (full spectrum), ensuring optimal synergy among its compounds for maximum efficacy.
Griffonia : Griffonia (Griffonia simplicifolia) a plant native to Africa, is renowned for its high content of 5-HTP (5-hydroxytryptophane), a direct precursor of serotonin, commonly referred to as the "happiness hormone." Griffonia is particularly valued for its ability to enhance brain activity and support emotional well-being.
Hericum erinaceus, also known as "Lion’s Mane" due to its unique appearance, is a leading medicinal mushroom in mycotherapy and widely appreciated in Asia for its health benefits. Its cognitive-support properties have been extensively studied. This mushroom's structure, characterized by long, hanging filaments resembling a lion's mane, sets it apart from other species, contributing to its evocative name and reputation.

PHYSIOMANCE^® GLP-1 Protect provides per 2 capsules (100% plant-based):

400 mg of Ginfort^® ginger extract (equivalent to 5.2 g of dried plant), titrated to 26% gingerols;
384.6 mg of Griffonia extract (equivalent to 1,538.4 mg of dried plant), titrated to 26% 5-HTP;
30 mg of Safr’Inside™ saffron extract (equivalent to 150 mg of dried plant), titrated to 2% safranal and 3% crocins;
225 mg of Hericium erinaceus extract (equivalent to 1.8 g of dried mushroom), titrated to 30% polysaccharides.

Patented Ginger Extract Ginfort^®

Ginfort^® is a patented ginger extract, highly concentrated in polyphenolic gingeroids, with 26% gingerols and shogaols.

This extract represents a major advancement in the use of ginger, a plant that has been used in Asia since 400 B.C. for its culinary and medicinal benefits on digestion, particularly to soothe gastrointestinal discomfort. Unlike traditional ginger preparations, Ginfort^® delivers 12 times more gingeroids and 6-gingerol thanks to its solvent-free extraction method and benefits from proven stability due to its unique proprietary technology.
This efficacy is optimized by :

The standardization of gingeroids by HPLC: Ginfort^® is standardized to contain a minimum of 26% gingeroids in a stable form, ensuring precise dosing of gingeroids.
Supercritical CO2 extraction without undesirable contaminants;

The Aqueosome^® technology, which increases the solubility and prolongs the release of lipophilic gingeroids (scarcely present in standard ginger extracts), thereby enhancing the absorption of these active compounds

This allows for a reduction in the amount of ginger consumed, from 2-4 g to just 200 mg of Ginfort^® ginger extract standardized to 26% gingeroids.
The effectiveness of Ginfort^® ginger, administered at a dosage of 200 mg twice daily for 28 days, has been demonstrated in a clinical study evaluating its impact on dyspeptic symptoms (nausea, bloating, flatulence, etc.). This study highlighted the superiority of the patented Ginfort^® extract, which stands out due to its highly concentrated formula, improved solubility, and proven efficacy. Moreover, Ginfort^® is safe and free from side effects.

Saffron patented Safr'Inside™

Safr’Inside™ is a patented saffron extract, standardized in crocins and safranal, that supports emotional balance by promoting a positive mood. Its patented process ensures optimal bioavailability through a unique encapsulation method, enabling rapid absorption and targeted action.
Safr’Inside™ saffron is derived from Sargol quality, a premium reference recognized for its exceptional purity and richness in active compounds. Unlike other varieties of saffron, Sargol is distinguished by a rigorous selection process that retains only the red tips of the stigmas, the part richest in active principles. No yellow or white residues from the pistil are included, ensuring optimal quality.
Our saffron extract has a broad spectrum of 25 molecules identified using HPLC analysis. This process preserves the full molecular spectrum of saffron, including volatile compounds like safranal, which are often lost during conventional extraction methods.
Its content is 10 times higher in safranal and 20 times more concentrated in crocins than standard extracts, enhancing the effects of saffron on emotional balance. Safr’Inside™ combines purity, efficacy, and innovation to provide comprehensive support for emotional well-being.

Furthermore, PHYSIOMANCE^® GLP-1 Protect delivers 30 mg of Safr’Inside™ saffron extract, corresponding to the dose used in clinical studies that have demonstrated its effectiveness.

Guranteed Naturality

Our products are developed with a genuine focus on quality and the efficacy of active ingredients!
Choose the best with PHYSIOMANCE^® GLP-1 Protect, a natural formula that adheres to THERASCIENCE's Clean Label^® standards! This label certifies natural formulations, from the selection of active ingredients to excipients, free from artificial colors and flavors, aspartame, titanium dioxide, GMOs, nanoparticles, irradiation, colloidal silica, preservatives, and animal testing, and manufactured in Europe. We pay particular attention to the origin, quality, and efficacy of our plant extracts. That is why we have developed the High Quality Process^®, a proprietary method that guarantees the origin, quality, and effectiveness of all our extracts.

The quality of our Safr’Inside™ saffron is rigorously controlled to ensure its authenticity and purity. DNA tests conducted by an accredited company certify that our saffron comes exclusively from the Crocus sativus species, with no admixture of other plants. Additionally, in compliance with ISO 3632 standards, analyses conducted by the DGCCRF confirm that our saffron is completely free of artificial colorants. Moreover, in collaboration with the CNRS (National Center for Scientific Research), we have developed a specific analytical method based on stable isotope measurement. This technique distinguishes natural safranal extracted from Crocus sativus from synthetic safranal, ensuring the complete absence of synthetic compounds in Safr’Inside™.

In addition, our hericium is sourced from organic farming, and PHYSIOMANCE^® GLP-1 Protect is encapsulated in 100% plant-based capsules for enhanced naturality. The THERASCIENCE Laboratory accommodates all dietary preferences: PHYSIOMANCE^® GLP-1 Protect is guaranteed to be gluten-free and lactose-free.