Zynamite®+ : a patented mango leaf extract with proven efficacy in improving intellectual performance
Present in many drinks (tea, coffee, mate), caffeine has many scientifically recognised virtues. In particular, it helps to improve alertness, intellectual performance and physical performance. Excessive consumption can, however, lead to side effects: agitation, adrenaline rush, nervousness, sleep disorders, stomach disorders and headaches, etc.
The patented mango leaf extract Zynamite®+ is a safe alternative, natural and sustainable alternative to caffeine without side effects.
Recent studies have shown that Zynamite®+ activates brain waves in a pattern almost identical to that of caffeine, but acting via a mechanism that does not cause the undesirable effects of caffeine.
Zynamite®+ is an extract standardised to 15% mangiferin. Unlike standard Zynamite® extract, it has the advantage of being soluble in aqueous solutions. Indeed, the action of pure mangiferin, present in standard Zynamite® standard, mango extract, is limited due to its low and fluctuating systemic bioavailability1,2, which is generally associated with its low aqueous solubility (0.111 mg/mL)3, and its low lipophilicity, which does not allow it to cross the intestinal membrane4. Zynamite®+ mango extract has a better bioavailability and a significantly higher absorption: 3.1 times higher than Zynamite® in 24h.
Characteristics of Zynamite®+ mango extract
Zynamite®+ improves mental and physical performance. Under conditions of cognitive stress, Zynamite®+ mango extract modulates neurotransmitter response, improving attention during cognitive tasks, improving reaction time and reducing cognitive fatigue while maintaining heart rate and blood pressure unchanged.
Clinical trials have shown that Zynamite®+ can stimulate cognitive function and aid decision making by reducing mental fatigue, increasing attention and concentration and improving reaction times.5
A randomised, double-blind, placebo-controlled clinical trial in 16 patients showed that taking 500mg of Zynamite®+ reduced mental fatigue by more than 40% and improved reaction times by 4.7% one hour after dosing, while the placebo group showed a 5.2% reduction in reaction times after one hour.5
Another double-blind, placebo-controlled crossover study of 70 healthy young adults given 300 mg of mango leaf extract showed significant improvements in brain performance on a range of cognitive tasks, including attention and memory, with effects lasting for at least five hours 6.
Zynamite®+ crosses the blood-brain barrier7, which makes it more effective.
(1)1) Liu, Y.; Xu, F.; Zeng, X.; Yang, L.; Deng, Y.; Wu, Z.; Feng, Y.; Li, X. Application of a Liquid Chromatography/Tandem Mass Spectrometry Method to Pharmacokinetic Study of Mangiferin in Rats. J. Chromatogr. B 2010, 878 (32), 3345–3350. https://doi.org/10.1016/j.jchromb.2010.10.014.
(2) Hou, S.; Wang, F.; Li, Y.; Li, Y.; Wang, M.; Sun, D.; Sun, C. Pharmacokinetic Study of Mangiferin in Human Plasma after Oral Administration. Food Chem. 2012, 132 (1), 289–294. https://doi.org/10.1016/j.foodchem.2011.10.079
(3) Wang, Z.; Deng, J.; Wang, Q.; Li, X.; WEI, H. Improvement in the Solubility of Mangiferin by HP-β-CD Inclusion. Chinese Tradit. Pat. Med. 2008, 30, 1123–1126.
(4) Tian, X.; Gao, Y.; Xu, Z.; Lian, S.; Ma, Y.; Guo, X.; Hu, P.; Li, Z.; Huang, C.Pharmacokinetics of Mangiferin and Its Metabolite—Norathyriol, Part 1: Systemic Evaluation of Hepatic First-Pass Effect in Vitro and in Vivo. BioFactors 2016, 42 (5), 533–544. https://doi.org/10.1002/biof.1291.
(5) López-Ríos, Laura et al. “Central nervous system activities of extract Mangifera indica L.” Journal of ethnopharmacology vol. 260 (2020): 112996. doi:10.1016/j.jep.2020.112996
(6) Wightman, E. L. et al. Acute effects of mango leaf extract (Zynamite®) on cognitive function in healthy adults: a double-blind, placebo- controlled, cross-over study. Nutrients12, 2194 (2020).
(7) Dimpfel, W. , Wiebe, J. , Gericke, N. and Schombert, L. (2018) Zynamite® (Mangifera indica Leaf Extract) and Caffeine Act in a Synergistic Manner on Electrophysiological Parameters of Rat Central Nervous System. Food and Nutrition Sciences, 9, 502-518.doi: 10.4236/fns.2018.95039.